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CBDA Research

Obesity and CBDA in Mice

antioxidant Effects + CBDA with CBD

CBDA effects on SARS-CoV-2

CBDA ameliorated obesity in associated with metabolic abnormalities in mice. 

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CBDA effects on SARS-CoV-2

antioxidant Effects + CBDA with CBD

CBDA effects on SARS-CoV-2

Cannabinoid acids from hemp were found to be allosteric as well as orthosteric ligands with micromolar affinity for the spike protein reducing entry of SARS-CoV-2 into the body.

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antioxidant Effects + CBDA with CBD

antioxidant Effects + CBDA with CBD

antioxidant Effects + CBDA with CBD

Metabolomic Profile and Antioxidant/Anti-Inflammatory Effects of Industrial Hemp Water Extract in Fibroblasts, Keratinocytes and Isolated Mouse Skin Specimens

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BCRP: drug efflux transporter

BCRP: drug efflux transporter

antioxidant Effects + CBDA with CBD

Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations

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MB-231: Breast Cancer

BCRP: drug efflux transporter

MB-231: Breast Cancer

Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration

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5-HT1A: nausea

BCRP: drug efflux transporter

MB-231: Breast Cancer

Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation

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Cancer, COx2, PPAR

Cancer, COx2, PPAR

Cancer, COx2, PPAR

Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation

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COX2: Inflammation

Cancer, COx2, PPAR

Cancer, COx2, PPAR

Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis

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dual PPAR agonists

Cancer, COx2, PPAR

dual PPAR agonists

Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach

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TRP channels

Rett syndrome

dual PPAR agonists

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on
TRP channels and endocannabinoid metabolic enzymes

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Rett syndrome

Rett syndrome

Rett syndrome

Chronic treatment with cannabidiolic acid (CBDA) reduces thermal pain sensitivity in male mice and rescues the hyperalgesia in a mouse model of Rett syndrome

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